Как спасти самого себя – 7 правил для больных болезнью Альцгеймера

Как спасти самого себя – 7 правил для больных болезнью Альцгеймера

Правила, которые названы «модифицируемым фактором риска болезни Альцгеймера и деменции» способны кардинально изменить жизнь больного. Подтверждены научными результатами.

Означают, что человек может самостоятельно управлять факторами, меняя свою жизнь и родных до такой степени, что риск тяжелых нейродегенеративных нарушений, разрушающих мозг последствий, значительно снижается.

Как спасти самого себя – 7 правил для больных болезнью Альцгеймера

Не стоит думать, что это банальные правила ЗОЖ. В этом вы убедитесь, прочитав исследования с вычислениями, в которых учеными указано, какую роль играют различные факторы на развитие деменции. А также, сколько людей могло избежать печальных последствий, соблюдая такие правила.

  1. Отказ от курения. Около 4,8 миллионов случаев заболевания деменции в мировой практике связаны с курением. Такой вывод сделан исследователями. Почему такое происходит? Все элементарно. Вредные токсины, попадающие при курении в наш организм, провоцируют воспалительные процессы на стенках кровеносных сосудов, а значит затрагивают и мозг. Результат – ускоренное накопление опаснейших амилоидных бляшек, приводящих к гибели нервных клеток нейронов. Ученые подсчитали, сокращение курения в мире на 30% спасет от старческого слабоумия более миллиона людей, склонных к заболеванию.
  2. Избавиться от ожирения в возрасте после 40 лет. Это касается тех, у кого ИМТ (индекс массы тела) превышает 30. Рассчитать свой индекс массы тела просто – возведением в квадрат роста в метрах, после чего массу в килограммах надо разделить на полученную цифру. Ученые уверяют, что примерно 679000 случаев деменции приходится на тех, у кого имеются сердечно-сосудистые заболевания, а ожирение является провоцирующим фактором их развития. Помимо этого к таким проблемам приводит плохой холестерин, повышенное артериальное давление. Вот как об этом рассказывает профессор популяционного здоровья и старения Университета Дьюка, научный директор и доктор наук из штата Каролины Соединенных Штатов Америки: «Есть даже такие сосудистые теории заболевания Альцгеймера, при которых мелкие сосуды головного мозга с возрастом или в результате вредных привычек начинают терять эластичность, становятся жесткими, начинается процесс разрушения. Все это вызывает проницаемость гематоэнцефалического барьера, который защищает мозг. Именно из-за сниженной защиты процесс ускоряется, болезнь активно развивается.
  3. Вести активный образ жизни. Около 4,4 миллионов случаев деменции связаны с сидячим или неактивным образом жизни. Это приводит к накоплению в организме опасных веществ, которые должны вымываться кровотоком. Достаточно заниматься физическими упражнениями не менее 2,5 часов в неделю, чтобы этого не произошло. В идеале – по 1 часу ежедневно. К самому безопасному виду физических нагрузок относится кардиологическая ходьба. Выполняется так, чтобы не было одышки, но при этом ускоренным шагом.
  4. Повышение самообразования. Недостаточный уровень самообразования способствует прогрессированию заболевания у 7 миллионов пациентов в мире. Важно создать с профилактической целью так называемые когнитивные резервы. Этого добиваются занятиями, ведущими к образованию новых связей между нейронами, благодаря чему стимулируется рост новых клеток (в небольшом количестве, но это важно). Самым мощным средством признано получение новых знаний, навыков. Например, можно начать посещение интересных познавательных лекций, овладеть компьютером, изучать иностранные языки, обучиться танцам, лепке, рисованию. Такие занятия требуют воспоминаний, запоминаний, что оказывает помощь в укреплении связи между нейронами.
  5. Своевременное выявление сахарного диабета и его правильное лечение. Около 876000 случаев развития старческого слабоумия возникают на фоне сахарного диабета. До конца связь болезни Альцгеймера с диабетом 2 типа пока не изучена. Большинство ученых предполагает, что у таких больных развита инсулинорезистентность (нечувствительность к гормону инсулину). Это приводит к плохому усвоению глюкозы вне мозга (на периферии). Раньше считалось, что инсулин не может оказывать влияния на метаболизм в мозге глюкозы. Недавние исследования доказали обратное. Существуют сложные механизмы, в результате которых шансы развития деменции повышаются при инсулинорезистентности. Поэтому заболеванию даже присвоено еще одно название – сахарный диабет 3 типа.
  6. Не допускать развития депрессий. Депрессивные состояния вызывают заболевание примерно в 4 миллионах случаев в мире. Сама по себе депрессия не указывает, что с мозгом что-то не так. Но при этом нейроны оказываются беззащитными перед зарождающимся процессом. Наблюдения за большой группой пациентов показали, что депрессивные состояния являются главным провоцирующим фактором развития деменции.
  7. Следить за артериальным давлением, не допуская развития гипертонии, особенно после 45-ти летнего возраста. Нелеченная гипертония вызывает заболевание примерно у 1,8 миллиона человек. Помимо этого, это угроза инсульта, инфаркта. Для справки, если человек не достиг возраста 65 лет, его верхнее (систолическое) давление не должно выходить за рамки 120-130 мм ртутного столба, а нижнее (диастолическое оставаться в пределах 70-80. Тем, кто старше, важно следить, чтобы показатели целевого давления не превышали 130-140 мм верхнего ртутного столбца, и 70-80 нижнего. Если показатели выше нормы, необходима консультация специалиста для своевременного принятия мер по понижению давления к нормам.

Научные факты

Исследование «Lifestyle for Brain Health», LIBRA», проводимое на протяжении 16 лет, показало, что основные факторы, снижающие риски болезни Альцгеймера, — употребление в пищу растительного масла (нерафинированного), отказ от алкоголя, придерживание специальной средиземноморской диеты (богатой на морепродукты, рыбу, фрукты, овощи), и высокая умственная активность.

Одновременно были выявлены факторы, которые повышают риск заболеть – сидячий уровень жизни, алкоголизм, большая масса тела, сердечно-сосудистые заболевания, почечные патологии, депрессии, высокий уровень холестерина в крови, сахарный диабет.

Есть и хорошие новости. Клинические испытания эффективности препаратов против деменции прошли успешно на нескольких группах пациентов. Новый препарат, разработанный биофармацевтической компанией Oryzon (Испания), значительно уменьшает агрессивность в исследованиях фазы Па. Одновременно, вакцина, разработанная от заболевания, по биотехнологии Axon Neuroscience от австрийской компании, снижает ключевые биомаркеры нейродегенерации в крови примерно на 65% в исследования фазы II.

Компанией Oryzon проводилось тестирование эпигенетического лекарственного средства, вафидемстата, контролирующего экспрессию генов, при которой не происходят изменения генетического кода. Препарат способен блокировать фермент LSD1, модифицирующий метилирования гистонов, поэтому, по предположению ученых, способен регулировать гены, которые связаны с развитием онкологических заболеваний и нейродегенеративного расстройства.

Согласно labiotech.eu, проверка препарата проводилось на протяжении полугода. Ее целью было проверить, как влияет вафидемстат на агрессию, возбуждение, характерное для больных деменцией в тяжелых и средних степенях. Был доказан благоприятный эффект. Отметилось как значительное снижение проявлений агрессивного состояния, так и снижение нагрузок по уходу за больными болезнью Альцгеймера.

Другие клинические результаты также получены от этого нового препарата. Исследования продолжались у 117 больных (фаза Па). После 6-ти месячного лечения значительно снизились ключевые воспалительные маркеры заболевания, под названием YKL 40.

Все эти исследования стали настоящим прорывом в лечении болезни, причиняющих страдания, как пациентам, так и их близким. Неврологическое заболевание, риск которого с возрастом повышается, теперь можно приостановить.

Это означает, что человек будет продолжать жить нормально, вести привычный образ жизни. Помимо этого, компания Axon Neuroscience также предоставила положительные результаты исследований II фазы вакцины, которая способна остановить прогрессирование старческого слабоумия.

Вакцина способна излечивать заболевание, благодаря активации иммунитета, направленной бороться с вредными белковыми формами (тау). Именно такие белки – одна из причин, которая вызывает болезнь Альцгеймера.

В результате 2-х летний испытаний вакцины, которая проводилась с пациентами в возрасте от 55 до 85 лет, ученые установили, что она способна успешно вырабатывать против тау антитела. Ключевой биомаркет при этом снижается примерно на 65%. Примечательный факт – у более молодых пациентов реакция была еще более успешной. Кровяной уровень легкой цепи нейрофиламента снижался почти на 72%.

Тренировка памяти – современные методики

Рекомендуется выполнять специальные упражнения (анти Альцгеймер) пациента после 75 лет.

  1. Эффективные поиски среди различных предметов.
  2. Использование таблицы Шульте.
  3. Регулярное выполнение гимнастики с пальцами.
  4. Заниматься поисками среди букв разных названий – растений, животных, овощей и прочего.
  5. Складывать в последовательности буквы алфавита, календарь.
  6. Отыскивать «не нужное» в группах слов, изображений.
  7. Заучивать наизусть устойчивые выражения, поговорки, пословицы.

Тем, у кого память функции сохранилась (начальные изменения) станет полезным записать мемуар или автобиографические воспоминания. И хотя болезнь Альцгеймера пока признана неизлечимой, отчаиваться не стоит. Исследования не прекращаются. Поэтому надежда на скорую победу остается.

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